Novel spontaneous myelodysplastic syndrome mouse model
نویسندگان
چکیده
منابع مشابه
Myelodysplastic syndrome.
The last decade has witnessed a multistep evolution in the understanding of the natural history, clinical manifestations, and some of the molecular mechanisms that underlie the ineffective hematopoiesis and leukemic transformation in the myelodysplastic syndrome (MDS). The international prognostic scoring system, FAB, and WHO classifications have helped define specific subgroups with their char...
متن کاملMyelodysplastic Syndrome
The hallmark of neoplastic disease, including myelodysplastic syndrome (MDS), is clonal proliferation of cells. Clonal proliferation is the consequence of acquired somatic mutation that confers a proliferative advantage to cells. For the myelodysplastic syndrome, the ability to identify clonally derived cells has provided valuable information about the molecular pathogenesis of the disease, the...
متن کاملMyelodysplastic syndrome.
During the past 15 years, important progress has been made in the understanding of the biology and prognosis of myelodysplastic syndrome (MDS). MDS is a clonal disorder characterized by ineffective hematopoiesis, which can lead to either fatal cytopenias or acute myelogenous leukemia (AML). Risk-adapted treatment strategies were established because of the high median age (60-75 years) of the MD...
متن کاملHyperuricemia and acute kidney injury secondary to spontaneous tumor lysis syndrome in low risk myelodysplastic syndrome
BACKGROUND This is a rare instance of acute kidney injury caused by hyperuricemia due to spontaneous tumor lysis syndrome and also the first case of spontaneous tumor lysis syndrome reported in association with myelodysplastic syndrome. CASE PRESENTATION A 53-year-old man presented with abrupt oliguria. Laboratory findings on admission included hyperuricemia, hyperphosphatemia, hypocalcemia, ...
متن کاملHyperuricemia and acute renal failure secondary to spontaneous tumor lysis syndrome in myelodysplastic syndrome
Background: This is a rare instance of acute renal failure caused by hyperuricemia due to spontaneous tumor lysis syndrome and the first case of spontaneous tumor lysis syndrome reported in myelodysplastic syndrome. Case Presentation: A 53-year-old man presented with abrupt oligouria. Laboratory findings on admission suggested hyperuricemia, hyperphosphatemia, hypocalcinemia, metabolic acidosis...
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ژورنال
عنوان ژورنال: Animal Models and Experimental Medicine
سال: 2021
ISSN: 2576-2095,2576-2095
DOI: 10.1002/ame2.12168